Relationship between serum miR-210 levels and PSA response in patients with metastatic castration resistant prostate cancer.

<p><i>Upper:</i> miR-210 copies/µl serum versus %PSA change/day. %PSA change/day represents a measure of response to treatment and was calculated using available clinical PSA values measured most recently prior to, and at the time of serum miR-210 draw. Mean time elapsed between the two blood draws was 30 days. Closed circles represent the subset of patients defined as "miRNA-high" based on higher abundance of mCRPC-associated serum miRNAs compared to all control individuals (as described in Results and Discussion). Open circles represent the patients with mCRPC who did not meet the definition for “miRNA-high”. Solid line represents trend line of the miRNA-high patient subset, dotted line represents trend line of all patients. <i>Middle:</i> miR-210 copies/µl serum in patients with either a PSA Response (R) or No PSA Response (NR). PSA Response is defined as a decreasing or stable PSA (any change less than a 25% increase), and No PSA Response is defined as a PSA increase of 25% or more, similar to the Prostate Cancer Working Group criteria. <i>Lower:</i> Copies/µl serum of miR-141, miR-200a, miR-200c and miR-375 in patients, R and NR.