<p>Wild type (WT) and mutant EGFP-tagged constructs of mouse PrP (A) and zebrafish PrP-1 (B) localize differently at E-cadherin-positive cell contact sites (in red). Marked areas on the overlays are enlarged (right) to show detailed views of the contact sites. Cell nuclei are stained with DAPI (blue). Scale bars = 10 µm.</p
Background: Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly unde...
<p>(<b>A</b>) Multiple sequence alignment of selected prion protein sequences with ZIP5 and ZIP10 or...
<p>(A–E) Left-most panels show transverse cryosections stained with phalloidin (red) to label actin ...
Analyses of cultured cells and transgenic mice expressing prion protein (PrP) deletion mutants have ...
Analyses of cultured cells and transgenic mice expressing prion protein (PrP) deletion mutants have ...
<p>The structural domains of zebrafish (zf) PrP-1, PrP-2 and mouse (m) PrP are represented as follow...
<p>(A) In wild-type zebrafish (left), PrP-1 promotes proper delivery of E-cadherin from the Golgi to...
<p>(A) In wild-type zebrafish (left), PrP-1 promotes proper delivery of E-cadherin from the Golgi to...
The prion protein (PrP) is a cell surface glycoprotein, best known for its key role in infectious br...
Prion proteins (PrPs) are key players in fatal neurodegenerative disorders, yet their physiological ...
The best-known attribute of the prion protein (PrP) is its tendency to misfold into a rogue isoform....
<p>Hippocampal neurons from C57BL/6J mice were transfected with a plasmid encoding PrP-EGFP (green)....
BACKGROUND: In early vertebrate development, embryonic tissues modulate cell adhesiveness and acto-m...
<p>Embryos were microinjected with mRNAs encoding all mouse and zebrafish EGFP-tagged PrP constructs...
<p>HeLa cells were transfected with either GFP alone (A, B), zebrafish Mypt1 (1-300) and GFP (C, D),...
Background: Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly unde...
<p>(<b>A</b>) Multiple sequence alignment of selected prion protein sequences with ZIP5 and ZIP10 or...
<p>(A–E) Left-most panels show transverse cryosections stained with phalloidin (red) to label actin ...
Analyses of cultured cells and transgenic mice expressing prion protein (PrP) deletion mutants have ...
Analyses of cultured cells and transgenic mice expressing prion protein (PrP) deletion mutants have ...
<p>The structural domains of zebrafish (zf) PrP-1, PrP-2 and mouse (m) PrP are represented as follow...
<p>(A) In wild-type zebrafish (left), PrP-1 promotes proper delivery of E-cadherin from the Golgi to...
<p>(A) In wild-type zebrafish (left), PrP-1 promotes proper delivery of E-cadherin from the Golgi to...
The prion protein (PrP) is a cell surface glycoprotein, best known for its key role in infectious br...
Prion proteins (PrPs) are key players in fatal neurodegenerative disorders, yet their physiological ...
The best-known attribute of the prion protein (PrP) is its tendency to misfold into a rogue isoform....
<p>Hippocampal neurons from C57BL/6J mice were transfected with a plasmid encoding PrP-EGFP (green)....
BACKGROUND: In early vertebrate development, embryonic tissues modulate cell adhesiveness and acto-m...
<p>Embryos were microinjected with mRNAs encoding all mouse and zebrafish EGFP-tagged PrP constructs...
<p>HeLa cells were transfected with either GFP alone (A, B), zebrafish Mypt1 (1-300) and GFP (C, D),...
Background: Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly unde...
<p>(<b>A</b>) Multiple sequence alignment of selected prion protein sequences with ZIP5 and ZIP10 or...
<p>(A–E) Left-most panels show transverse cryosections stained with phalloidin (red) to label actin ...