Effect of the speed of the phosphorylation module.

<p>The results have been obtained for the same equations as in Fig. 5. The kinetic parameter values of the phosphorylation module have been decreased by a factor 100 compared to Fig. 5. The other parameter values are the same as in Fig. 5. The trajectory of the complete system does not match the steady state curve because the dynamics of is not sufficiently fast (Panel A). Nevertheless the oscillations are not significantly affected compared to the 3-variable model (see Fig. 7 for a comparison of the limit cycles). Due to a slowing down of the dynamics, the period (54 a.u.) is longer than the oscillation period in the 3-variable model.