Group characteristics (continuous variables) at baseline (A) and 2-year follow-up (B).

<p>Abb. UPDRS-III: Unified Parkinson’s Disease Rating Scale, motor section; MMSE: Mini Mental State Examination; FAB: Frontal Assessment battery; HADS: Hospital Anxiety Depression Scale; HADS-D: Hospital Anxiety Depression Scale-depression subscale; HADS-A: Hospital Anxiety Depression Scale-anxiety subscale; NMS: non-motor symptoms; NMS-D: non-motor domains; LEDD: Levo-dopa equivalent daily dosage.</p>a<p>different from group 4 (p<0.01).</p>b<p>different from group 1 (p<0.01).</p>c<p>different from all groups (p<0.01).</p>d<p>different from group 2 and 4 (p<0.01).</p>e<p>different from group 2 (p<0.01).</p>f<p>different from group 1 and 3 (p<0.01).</p>g<p>different from group 1 and 2 (p<0.01).