<p>The IC50 of different small molecule inhibitors against the lipid kinase activity of wildtype and mutant p110α.</p
SA51, a medium potency inhibitor of protein tyrosine phosphatase 1B (PTP1B), was identified to be a ...
<p>Structures and PKD1 inhibitory activities of selected small molecule inhibitors identified in pre...
<p>Fold changes in IC50 and fractional changes in the slopes of the inhibition curves of various dru...
<p>(A) HEK 293T cells were transfected with p85 and wild type or E633K myc-p110β. Anti-myc immunopre...
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targ...
In this issue of Cell, Knight et al. (2006) present a detailed pharmacological analysis of the PI3 k...
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targ...
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targ...
<p>A list of PKD inhibitors that had ≤50% inhibitory activity for PKCα, PKCδ or CAMKIIα at 10 µM. Co...
AbstractSome protein kinases are known to acquire resistance to selective small molecule inhibitors ...
Point mutations emerge as one of the rate-limiting steps in tumor response to small molecule inhibit...
<p>The IC<sub>50</sub> values of the kinase inhibitors towards B lymphoma cell lines and PBMCs are s...
Many clinically validated kinases, such as BCR-ABL, c-Kit, PDGFR and EGFR, become resistant to ATP-c...
BACKGROUND: The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα) has protein kinase activ...
Summaryp110α (PIK3CA) is the most frequently mutated kinase in human cancer, and numerous drugs targ...
SA51, a medium potency inhibitor of protein tyrosine phosphatase 1B (PTP1B), was identified to be a ...
<p>Structures and PKD1 inhibitory activities of selected small molecule inhibitors identified in pre...
<p>Fold changes in IC50 and fractional changes in the slopes of the inhibition curves of various dru...
<p>(A) HEK 293T cells were transfected with p85 and wild type or E633K myc-p110β. Anti-myc immunopre...
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targ...
In this issue of Cell, Knight et al. (2006) present a detailed pharmacological analysis of the PI3 k...
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targ...
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targ...
<p>A list of PKD inhibitors that had ≤50% inhibitory activity for PKCα, PKCδ or CAMKIIα at 10 µM. Co...
AbstractSome protein kinases are known to acquire resistance to selective small molecule inhibitors ...
Point mutations emerge as one of the rate-limiting steps in tumor response to small molecule inhibit...
<p>The IC<sub>50</sub> values of the kinase inhibitors towards B lymphoma cell lines and PBMCs are s...
Many clinically validated kinases, such as BCR-ABL, c-Kit, PDGFR and EGFR, become resistant to ATP-c...
BACKGROUND: The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα) has protein kinase activ...
Summaryp110α (PIK3CA) is the most frequently mutated kinase in human cancer, and numerous drugs targ...
SA51, a medium potency inhibitor of protein tyrosine phosphatase 1B (PTP1B), was identified to be a ...
<p>Structures and PKD1 inhibitory activities of selected small molecule inhibitors identified in pre...
<p>Fold changes in IC50 and fractional changes in the slopes of the inhibition curves of various dru...
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