A53T homozygote mice develop gross motor abnormalities with age.

<p>In the open field, results from spontaneous locomotor testing indicate A53T mice travel significantly greater distances than wild type littermates at 6 and 12 months (A). Digigait analysis shows the stride length and frequency (steps per second) are significantly decreased in 12 month A53T mice compared to wild type littermates (t-test analysis within age group- data represent both hind limbs (B). The combined latency to fall from 5 individual trials shows A53T mice exhibit enhanced rotarod latency that declines with age (C). Graphs are representative of data collected from 2–3 independent cohorts of animals with 8–15 mice per group. Data plotted as Mean+/− SEM. Bonferonni post hoc test *p<0.05, **p<0.001; s = seconds, cm = centimeters, M = month, WT = wild type, HO = homozygous.