Murine CXCL13 levels are greatly elevated in the serum and ascites of mice with 2F7-derived AIDS-BL tumors.

<p>(<b>A</b>) Murine CXCL13 levels in the serum of control mice (n = 13) and in the serum of mice with tumors (n = 14), as determined by ELISA. (<b>B</b>) Murine CXCL13 levels in the ascites fluid of the mice with tumors. The solid square within each box plot represents the mean value for the data. In (<b>A</b>), there is an ~20-fold increase in mean mCXCL13 levels in the serum of mice with tumors compared to control mice (p < 0.0001; t-test). In (<b>B</b>), the long lower whisker in the box plot of the data reflects the presence of several low outliers; these lower values were generally seen in animals that developed smaller, more localized tumors at the site of injection as opposed to widespread metastatic disease.