SnoN Overexpression Overcomes TGF-β1 Inhibition.

<p>(<b>A</b>) Neurite outgrowth in primary adult DRG neurons in the presence of TGF-β1. Cells expressing GFP and NF200 (shown) are quantified. (<b>B</b>) Overexpression of SnoN in neurons appears to increase neurite length even in presence of TGF-β1, quantified in D. (<b>C</b>) Overexpression of SnoN-D-box mutation also appears to increase neurite growth. (<b>D</b>) Quantification reveals that overexpression of TGF-β1 overcomes TGFß-1-mediated inhibition (ANOVA p<0.001; post hoc Fisher’s *p<0.05, **p<0.01).