Schematic diagram of drug treatment, tissue preparation and behavioral tests.

<p>Mice were treated with lithium chloride (50 mg/kg, i.p.) 0 and 24 h after TMT (2.6 mg/kg, i.p.) injection. Then, mice were monitored and seizure scored for 5 consecutive days. Learning and memory tests (novel object recognition memory and Morris water maze) were performed after disappearance of TMT-induced seizures (7 days post-treatment). Circles indicate the time-points at which were sacrificed and tissue was sampled.