Protective effect of ETs from blackberry and raspberry against ethanol induced gastric injury.

<p>Wistar rats were randomly divided in 5 groups (6 rats in each group). Controls were treated daily with vehicle (10% polyethylene glycol 400; PEG 400) for 10 days. Ethanol group received the vehicle (10% PEG 400) daily for 10 days, and then 1 ml of ethanol. ETblack group received 20 mg/kg of blackberry ETs dissolved in 10% PEG 400 for 10 days, and then 1 ml of ethanol. ETrasp group recived 20 mg/kg of raspberry ETs dissolved in 10% PEG 400 for 10 days, and then 1 ml of ethanol. Quercetin group (positive control) received 100 mg/kg of quercetin dissolved in 10% PEG 400 for 10 days, and then 1 ml of ethanol. The last administration of ETs, quercetin or vehicle was given 120 min before ethanol. Treatment was performed intragastrically by gavage. Gastric damage was assessed in a blind manner by a scoring system based on the number and severity of the lesions: 0, no lesions; 1, lesions 1–2 mm; 2, lesions 2–3 mm; 3, lesions >3 mm. Ulcer Index was calculated as the total number of lesions multiplied by their respective severity score. Results are the mean ± se, n = 6. ***p<0.001.