RXR-γ interacts with a number of nuclear receptors and modulates cellular differentiation.

<p>A. Co-Immunoprecipitation (Co-IP) with RXR-γ showing eluted Immunocomplex by silver staining. B. Validation of RXR-γ indicating interaction in Co-IP with RXR-γ with PPAR-γ, RAR-γ, RXR-α and RAR-α in A4-P cells validated through immunoblotting. C. Expression profiling of CK-18, Muc-1 and E-Cadherin at transcriptional (Tr) and protein (Pr) performed by semi-quantitative RT-PCR and immunoblotting in CRA, ADA or TTNPB retinoids treated A4-P (P) and A4-T (T) cells. D. Quantitation of mRNA expression of E-Cad, CK18 and MUC1 epithelial differentiation markers in A4-P (P; line) and A4-T cells (T; dashed line) upon retinoids treatment validated through RT-PCR. E. Quantitation of protein expression of E-Cad, CK18 and MUC1 makers in A4-P (P; line) and A4-T cells (T; dashed line) upon retinoids treatment validated through immunoblotting. Data shown are representative of three separate experiments depicted as mean ± SEM *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001.