Glucose depletion synergized cytotoxicity of PPARα antagonist but not agonist.

<p>A. RCC cells (Caki-1 and 786-O) were treated with DMSO (Cont), GW6471 (GW) 25 µM, and/or 2-DG (5 mM) for 72 hours and cell viability assay was performed as described in Materials and Methods. B. RCC cells (Caki-1 and 786-O) were treated with DMSO (Cont), GW6471 (GW) 25 µM, low glucose media (Lo Glu), or GW6471 in low glucose for 72 hours and cell viability was assessed by an MTT assay as described in Materials and Methods. The data shown are representative of at least three repeats. **Synergistic effect compared to each treatment separately. Error bars indicate standard deviation.