Flowchart of manual and semiautomatic segmentation analysis.

<p>Structural imaging (CE-T1WI or T2WI) and nCBV maps were coregistered using the manual segmentation method, and then the ranges of tumors were manually depicted by each observer using an ROI <b>(right row)</b>. Structural imaging (CE-T1WI or T2WI) and nCBV maps were coregistered using the semiautomatic segmentation method; then, the ranges of tumors were depicted by each observer using a VOI. Finally, an appropriate combination of clusters from the various clusters was determined by each observer <b>(left row)</b>. CE-T1WI = contrast enhanced T1-weighted imaging; T2WI = T2-weighted imaging; nCBV = normalized cerebral blood volume; ROI = region of interest; VOI = volume of interest.