Leflunomide inhibits cell growth in neuroblastoma.

<p>A. Morphologic examination of neuroblastoma cell lines either untreated or treated with leflunomide 100 µM for 72 hours respectively. <i>Scale bar</i>, 50 µm. B. The cell counting of BE(2)-C, SK-N-DZ, and SK-N-F1 cells after 100 µM leflunomide treatment for 72 hours, DMSO as control. Data represent the average ± SD of at least three independent experiments. **, p<0.001. C. BE(2)-C, SK-N-DZ, and SK-N-F1 all three cell lines were treated with 12.5, 25, 50, 100, and 200 µM leflunomide, DMSO was used as a control. Cell growth was tested by the CCK-8 assay every 2 days. Data represent the average ± SD of at least three independent experiments.