Effects of the infusion of muscimol into the hippocampus 30 min before daily conditioning training during the inactivation phases (phases I and III) on delay eyeblink conditioning with the soft tone CS.

<p>MAMA, muscimol-ACSF-muscimol-ACSF infusion; AAAA, ACSF-ACSF-ACSF-ACSF infusion. A solid red line and dash blue line represents muscimol or PBS infusion, respectively. (A–C) The mean value ± standard error (SEM) for the percentage (A), peak magnitude (B), onset latency (C), and peak latency (D) of the CR with the soft tone CS in the Soft-MAMA (n = 8, green triangle) and Soft-AAAA (n = 10, green circle) groups. (E, F) Averaged eyelid responses of all trials in the Soft-MAMA (E) and Soft-AAAA (F) animals across thirty consecutive training sessions. Note that there were only significant differences in the percentage and peak magnitude of the CR between the Soft-MAMA and Soft-AAAA groups in phases I, II and III. *<i>p</i><0.05 versus control. The error bars represent the SEM.