RMP hyperpolarization restores spike amplitude and accentuates post-excitatory membrane hyperpolarization in myelinated Ah-type VGNs from adult, non-ovariectomized rats.

<p><b>A</b>) Train of vagal stimulation-evoked action potentials (50 Hz) in an Ah-type neuron under zero current-clamp condition. Note the decline in spike amplitude with increasing number of evoked action potentials, and a small-amplitude PEMH. <b>B</b>) – <b>J</b>) Effect of hyperpolarizing current injection on vagal stimulation-evoked action potentials. Numbers at the beginning and end of each trace denote the initial RMP and the minimal membrane potential during a PEMH, respectively. Hyperpolarizing currents were applied throughout the recordings, including the post-tetanic period. Vagal stimulation frequency was 50 Hz. Trains of action potentials during vagal stimulation Scale bars in (<b>F</b>) apply to all panels.