Myofibroblast differentiation in human normal (HNL), cystic fibrosis (CF) and idiopathic pulmonary fibrosis (IPF) lung tissue.

<p>A) Immunohistochemical staining for α-smooth muscle actin (α-SMA), the contractile element in myofibrobroblasts. Myofibroblast accumulation is significantly accentuated in cystic fibrosis (CF) and idiopathic pulmonary fibrosis (IPF) compared to non-diseased controls. Images at 100× (bar = 250 µm). B) Comparison of myofibroblast differentiation in HNL, CF and IPF lung tissue analyzed semi-quantitatively. C) Comparison of myofibroblast differentiation in HNL, CF and IPF lung tissue analyzed by quantitative morphology. D) Correlation between semiquantitative and quantitative measures of myofibroblast differentiation in HNL, CF and IPF lung tissue specimens. E) Myofibroblast differentiation versus tissue fibrosis in HNL, CF and IPF lung tissue specimens.