Increased peripheral lung fibrosis in cystic fibrosis (CF).

<p>A) Histochemical staining for fibrosis (Masson trichrome stain, collagen shown in blue) in human normal lung (HNL), cystic fibrosis (CF) and idiopathic pulmonary fibrosis (IPF). Images are shown at approximately 100× from 2 separate HNL, CF and IPF specimens (bar = 250 µm). B) Comparison of collagen deposition (Masson trichrome stain) by semiquantitative analysis and C) quantitative morphometry. D) Correlation between quantitative morphometry (% collagen deposition) and semiquantitative analysis (1–5 scale).