Expression of CTGF, TSP1 and Fibronectin (Fn) is increased, while nephrin is decreased in kidney cortices from diabetic wildtype mice, but attenuated in diabetic heterozygous animals (A).

<p>Similar findings were observed for CTGF, Nephrin, TSP1 and Fn proteins (<b>B to F</b>). Total RNA and protein were extracted from PBS-perfused kidney tissues; mRNA levels were determined by qRT-PCR whilst protein was assessed by Western Blotting Analysis. Values represent mean ± SD, n = 4. *p<0.05 vs -NonDM+/+; <b>#</b>p<0.02 vs NonDM+/+; †P<0.05 vs NonDM+/−; §p<0.05 vs DM+/−.