The miRs expression in cells under inflammatory challenages.

<p>(A) The expression of miR-155 in asthmatic and normal lung tissues of mice. (B) Examination of hyperstretch-regulated miRs, where miR-155 was significantly increased. (C) Hyperstretch regulation of miR-155 in hBECs with or without hMSCs co-culture. Expression levels of hBEC miR-155 in mono-culture (first four bars), and in co-culture (5^th and 6^th bar) after treatments with (D) IL-10 antibodies, and (E) IL-10 receptor [IL-10R] blocking antibodies. The results demonstrated that hMSCs and IL-10 had similar effects on up-regulation of hyperstretch-induction miR-155 expression in hBEC. The changes in secretion level are relative to static control. Data represent mean ± s.e.m. *, P<0.05; **, P<0.01 n = 5.