Metabolic analysis of A315T line 61 mice.

<p>(<b>A</b>–<b>D</b>) Cumulative values from individual mice over 96 hours for horizontal X/Y activity (<b>A</b> and <b>B</b>), vertical Z activity (<b>C</b>) and food intake (<b>D</b>) from non-transgenic and A315T line 61 mice in metabolic cages. (<b>E</b>) Food intake normalized to weight for A315T line 61 and non-transgenic controls for a 96 hour period. (<b>F</b>) Energy expenditure normalized to lean mass (10 weeks of age; N=6 each group). Bar =mean±S.E.M. (<b>G</b>-<b>K</b>) Fasting blood values for glucose (<b>G</b>), cholesterol (<b>H</b>), triglycerides (<b>I</b>), gamma glutamyltransferase (<b>J</b>), and creatine kinase (<b>K</b>) in non-transgenic and A315T line 61 mice (8-16 weeks, N= 4-9). (<b>L</b>) Glucose tolerance test in non-transgenic and A315T line 61 mice (N=5-12).