ICOS<sup>-/-</sup> lymphocytes do not protect from CD8-mediated lung injury in mice.
- Qiang Wu (31071)
- Gail J. Gardiner (445014)
- Elizabeth Berry (169667)
- Sarah R. Wagner (445015)
- Tiffany Lu (445016)
- Bryan S. Clay (355764)
- Tamson V. Moore (355763)
- Caroline M. Ferreira (188602)
- Jesse W. Williams (355766)
- Andrew D. Luster (199904)
- Benjamin D. Medoff (133569)
- Judy L. Cannon (355767)
- Anne I. Sperling (355769)
- Rebecca A. Shilling (355768)
Publication date
August 2013
DOIAbstract
<p>CC10-OVA.RAG<sup>-/-</sup> mice were injected with wild-type LN/spleen cells, ICOS deficient LN/spleen cells, or ICOS deficient LN/spleen cells co-transferred with 0.5x10<sup>6</sup> or 1x10<sup>6</sup> ICOS<sup>+/+</sup> Tregs 2 days prior to i.v. injection of activated 1x10<sup>5</sup> OT-I T cells. (A) Survival (B) Total lung cells, percentage and absolute numbers of CD4<sup>+</sup>, CD4<sup>+</sup>Foxp3<sup>+</sup> T cells. (C) Percentage and absolute number of OT-I. Thy1.1<sup>+</sup> cells and CD8<sup>+</sup> Thy1.2<sup>+</sup> T cells. (D) Percentage and absolute number of OT.I. Thy1.1<sup>+</sup> T cells and CD8<sup>+</sup>Thy1.2<sup>+</sup> T cells expressing IFNγ or TNFα in the lungs at Day 4 were measured.</p
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