<p>The structures of BC8-15 and two structurally-related derivatives are shown. The IC<sub>50</sub> values of each compound were determined by <i>in vitro</i> PDE assays (see Material and Methods). The values represent mean IC<sub>50</sub>± SD determined from three independent experiments.</p
<p>Chemical structures and ZINC codes of the 10 compounds suggested to be PPARγ partial agonists and...
<p>IC<sub>50</sub> of the synthesized 1j derivative on six different cell lines.</p
<p>Tyrosinase IC<sub>50</sub> values (μM) for the compounds tested in this study.</p
<p>Structures and IC<sub>50</sub> values of the studied ligands 1a, 1b and 2.</p
<p>IC50 values have been determined using the same conditions as in the primary assay in the presenc...
<p>Chemical structures of the five lead compounds selected for <i>in vivo</i> studies.</p
<p>IC<sub>50</sub> values for compounds tested against <i>Bm</i>DHFR and <i>Wb</i>DHFR.</p
<p><sup><b>a</b></sup> Coefficient of variation for all IC<sub>50</sub>’s were lower than 1%</p><p>I...
<p>Chemical structures and IC50 values of the training and test set molecules.</p
<p>Contents of seven compounds in different samples and the result of total IC<sub>50</sub> values (...
<p>The calculated <i>k’</i> values of novel compounds and standard antioxidants in the BCB assay.</p
<p>IC<sub>50</sub> values of compounds MP5-F9, MP5-G9, and CA4 in various cancerous cell lines.</p
<p>The dashed lines represent a 2-fold over- or underestimation compared with <i>in vivo</i> Cu,br/C...
<p>Dot plot depicting the IC<sub>50</sub> values for the most potent 1,359 compounds in 7H9 OADC and...
<p>Chemical structure of the drugs with TRPM8 antagonist activity used in this study.</p
<p>Chemical structures and ZINC codes of the 10 compounds suggested to be PPARγ partial agonists and...
<p>IC<sub>50</sub> of the synthesized 1j derivative on six different cell lines.</p
<p>Tyrosinase IC<sub>50</sub> values (μM) for the compounds tested in this study.</p
<p>Structures and IC<sub>50</sub> values of the studied ligands 1a, 1b and 2.</p
<p>IC50 values have been determined using the same conditions as in the primary assay in the presenc...
<p>Chemical structures of the five lead compounds selected for <i>in vivo</i> studies.</p
<p>IC<sub>50</sub> values for compounds tested against <i>Bm</i>DHFR and <i>Wb</i>DHFR.</p
<p><sup><b>a</b></sup> Coefficient of variation for all IC<sub>50</sub>’s were lower than 1%</p><p>I...
<p>Chemical structures and IC50 values of the training and test set molecules.</p
<p>Contents of seven compounds in different samples and the result of total IC<sub>50</sub> values (...
<p>The calculated <i>k’</i> values of novel compounds and standard antioxidants in the BCB assay.</p
<p>IC<sub>50</sub> values of compounds MP5-F9, MP5-G9, and CA4 in various cancerous cell lines.</p
<p>The dashed lines represent a 2-fold over- or underestimation compared with <i>in vivo</i> Cu,br/C...
<p>Dot plot depicting the IC<sub>50</sub> values for the most potent 1,359 compounds in 7H9 OADC and...
<p>Chemical structure of the drugs with TRPM8 antagonist activity used in this study.</p
<p>Chemical structures and ZINC codes of the 10 compounds suggested to be PPARγ partial agonists and...
<p>IC<sub>50</sub> of the synthesized 1j derivative on six different cell lines.</p
<p>Tyrosinase IC<sub>50</sub> values (μM) for the compounds tested in this study.</p