Treatment with AICAR attenuates the catabolic effects of streptozotocin (STZ)-induced diabetes on body composition.

<p>Lean body mass (LBM) (A), soleus (Sol) (B), extensor digitorum longus (EDL) (C), and epitrochlearis (Epit) (D) muscles, and viscera (E) masses were measured in control (Con, saline-injected), AICAR-injected (A), STZ, and STZ plus AICAR (STZ+A) rats at the end of the study. *P<0.05 vs. Con, A, and STZ+A. ^#P<0.05 vs. Con, A, and STZ. ^‡P<0.05 vs. Con and A. (One-way ANOVA, N = 8).