Temporal dynamics of GABA and DA neuron activity in response to 1 µM nicotine in case α4β2 receptor desensitization is driven by Nic <i>and</i> ACh.

<p>(A,C) GABA (A) and DA (C) neuron activity in the direct stimulation case (same as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003183#pcbi-1003183-g004" target="_blank">Fig. 4C,E</a> full blue lines; , µM, , ) for different efficacies of ACh to drive α4β2 receptor desensitization (η given in panel A). (B,D) GABA (B) and DA (D) neuron activity in the disinhibition case (, µM, , ) for different efficacies of ACh to drive α4β2 receptor desensitization (η given in panel B, see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003183#s4" target="_blank">Models</a>).