Genetic interactions between genes involved in dityrosine layer formation.

<p>Cytoscape was used to represent the genetic interactions listed in Table S1. Lines between the circles indicate reduction of dityrosine fluorescence in the double mutant. Double mutants were constructed from two independent pairs of parental strains and tested in three biological replicates (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003700#s4" target="_blank">Methods</a>). Arrowheads indicate whether the interaction was seen in one (one arrowhead) or both (two arrowheads) double mutant strains. Circles in darker purple indicate genes with >10 interacting partners. The size of the circles increases with the number of genetic interactions seen for each gene.