Genes demonstrating genome-wide significant evidence of rare variant association with type-1 diabetes on chromosome 6.

a<p>Genes with a permuted p-value less than 1.7×10⁻⁶ (indicating genome wide significance assuming a significance level of 5% and that there are 30,000 genes in the human genome <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003694#pgen.1003694-3" target="_blank">[25]</a>) in a Generalised C-alpha test.</p>b<p>For these genes, results are also shown when effects are adjusted for the lead common MHC SNP (rs9268645). Both analyses are adjusted for 3 principal components to account for population structure. For the unconditional analysis results are based on 600,000 permutations; for the conditional analysis results are based on 575,000 permutations. MAF, minor allele frequency; BP, base pair; MAF: Minor Allele Frequency; MHC, Major histocompatibility complex; NCBI, National Center for Biotechnology Information.