<p>Double mutants for <i>cat-2</i> and <i>tbh-1</i> (A), <i>ser-3</i> (B), or <i>crh-1</i> (C) were examined for paralysis on NGM plates containing 1 mM aldicarb. (D-F) The time required for 50% of the animals to become paralyzed was determined using Prism. <i>tbh-1</i>, <i>ser-3</i>, and <i>crh-1</i> single mutants exhibited similar aldicarb sensitivity to wild-type N2 animals. The aldicarb resistance observed in the <i>cat-2</i> mutant was significantly reduced in the <i>cat-2;tbh-1</i>, <i>cat-2;ser-3</i>, and <i>cat-2,crh-1</i> double mutants. *P<0.001 by the Tukey-Kramer multiple comparison test. Error bars indicate the SEM.</p
<p>(A) Tyramine induces immobilization in a dose-dependent manner. Shown is the percentage of animal...
<p>(<b>A</b>) In either WT or <i>daf-2</i>(<i>RNAi</i>) background, <i>hq6</i> conferred resistance ...
<p>(A) Representative fluorescent images of WT and <i>casy-1</i> mutant animals expressing GFP in al...
<p><i>cat-2;crh-1</i> mutants were transformed with <i>ceh-17::crh-1</i> and the co-injection marker...
<p>The choline acetyltransferase gene <i>cha-1</i> was specifically knocked down by RNAi in the SIA ...
<p> The paralytic response to aldicarb treatment was analyzed in strains containing mutations that i...
<p>(A) Cholinergic neuronal transmission was measured by determining the onset of paralysis induced ...
(A) The drug aldicarb inhibits acetylcholinesterase and leads to acetylcholine build-up at the neuro...
<p>Animals placed on 0.5 mM aldicarb, an acetylcholine esterase inhibitor, or levamisole, an acetylc...
For mutant alleles tested for aldicarb sensitivity see Table S1. Alleles used for aldicarb resistant...
<p><b>A-B.</b> Paralysis of wild type and mutant <i>C</i>. <i>elegans</i> on NGM agar plates. <b>A.<...
<p>Levels of ACh secretion were assayed by following the time course of paralysis of animals on 1 mM...
<p>Rates of worm paralysis of the indicated strains when exposed to aldicarb. (A) Expression of WDR-...
Mutants N2-1, N2-2, N2-3 is compared with N2 mutant at carbendazim 250, 500, 750 and 1000 μg/ml in P...
<p>(A) Convulsion frequency of <i>acr-2(gf)</i> in combination with loss of function (lf) mutations ...
<p>(A) Tyramine induces immobilization in a dose-dependent manner. Shown is the percentage of animal...
<p>(<b>A</b>) In either WT or <i>daf-2</i>(<i>RNAi</i>) background, <i>hq6</i> conferred resistance ...
<p>(A) Representative fluorescent images of WT and <i>casy-1</i> mutant animals expressing GFP in al...
<p><i>cat-2;crh-1</i> mutants were transformed with <i>ceh-17::crh-1</i> and the co-injection marker...
<p>The choline acetyltransferase gene <i>cha-1</i> was specifically knocked down by RNAi in the SIA ...
<p> The paralytic response to aldicarb treatment was analyzed in strains containing mutations that i...
<p>(A) Cholinergic neuronal transmission was measured by determining the onset of paralysis induced ...
(A) The drug aldicarb inhibits acetylcholinesterase and leads to acetylcholine build-up at the neuro...
<p>Animals placed on 0.5 mM aldicarb, an acetylcholine esterase inhibitor, or levamisole, an acetylc...
For mutant alleles tested for aldicarb sensitivity see Table S1. Alleles used for aldicarb resistant...
<p><b>A-B.</b> Paralysis of wild type and mutant <i>C</i>. <i>elegans</i> on NGM agar plates. <b>A.<...
<p>Levels of ACh secretion were assayed by following the time course of paralysis of animals on 1 mM...
<p>Rates of worm paralysis of the indicated strains when exposed to aldicarb. (A) Expression of WDR-...
Mutants N2-1, N2-2, N2-3 is compared with N2 mutant at carbendazim 250, 500, 750 and 1000 μg/ml in P...
<p>(A) Convulsion frequency of <i>acr-2(gf)</i> in combination with loss of function (lf) mutations ...
<p>(A) Tyramine induces immobilization in a dose-dependent manner. Shown is the percentage of animal...
<p>(<b>A</b>) In either WT or <i>daf-2</i>(<i>RNAi</i>) background, <i>hq6</i> conferred resistance ...
<p>(A) Representative fluorescent images of WT and <i>casy-1</i> mutant animals expressing GFP in al...