IQ extends survival time in a mouse model for prion diseases.

<p>Transgenic mice overexpressing ovine PrP were intraperitoneally infected with scrapie. 12 mice were treated with DMSO (control group) and 12 mice were treated with IQ solubilised in DMSO (IQ group) until the appearance of the first clinical signs in mice from the control group at day 90. <b>A</b>. Survival time of mice treated with DMSO (control group) or mice treated with IQ (IQ group). <b>B</b>, <b>C</b>. Effects of IQ on PrP^Sc accumulation in scrapie-infected mouse spleens. The spleen of 3 mice euthanized at 56 days post-inoculation (<b>B</b>) and the spleen of 4 mice euthanized at terminal stage (<b>C</b>) from both control and IQ groups were analyzed for PrP^Sc content. The PrP^Sc content of spleens was determined by Western blot. The same amount of spleen tissue proteins was loaded on each well.