HFD accelerates the development of intestinal inflammation.

<p>WT and TNF^ΔARE/WT mice were fed control diet or HFD from the age of 4 weeks until the age of 8, 12 or 16 weeks. H&E stained sections of distal ileum (A, B) and proximal colon (C) were blindly assessed for the degree of histopathology. Data sets with different superscript letters differ significantly from each other. Disease activity index (DAI) was assessed as a combined score of weight loss, stool consistency and blood in stool (D). n = 6 per group for 8 weeks and 12 weeks, n = 9 per group for 16 weeks timepoint; Data sets with different superscript letters differ significantly from each other according to two-way ANOVA: a,b within 8 weeks, a’, b’ within 12 weeks, a”, b” within 16 weeks timepoint. *p<0.05 **p<0.01 ***p<0.001 between dietary groups within the same genotype according to Student’s t-test.