The Allosterically Communicating Residues in the Hsp90-Aha1 Complex.

<p>The functional dynamics profiles of the Hsp90-Aha1 complexes with the Aha1-N domain (A) and the complete Aha1 molecule (B). A ribbon-based representation of the Aha1 domains is combined with a surface view of the Hsp90 dimer. The color gradient from blue to red indicates the decreasing structural rigidity of protein residues as in previous figures. (C) The distribution of allosterically in the context of the functional dynamics profile. The location and identities of allosterically communicating residues are annotated in spheres colored according to their respective mobility level. The crystal structure of yeast Hsp90 is enveloped in a 50% transparent molecular surface to show the location of the allosterically communicating residues. The three-helix bundle that links the inter-domain regions is shown in ribbon representation.