<p>Time-course analysis of cavernosal arginase activity at pre-diabetic stage (4 wks of age) and diabetic (12 and 24 wks of age) stage (panel <b>A</b>). Pretreatment with (S)-(2 boronoethyl)-L-cysteine (BEC, 100 µmol/l, an arginase inhibitor) significantly prevented these increases. Levels of both arginase 1 (Arg1) and arginase 2 (Arg2) were markedly increased in pre-diabetic (panel <b>B</b>) and diabetic (panel <b>C</b> and <b>D</b>) Akita mice. Values are expressed as mean ± S.E.M. of 4–5 independent experiments. * <i>p</i><0.05; ** <i>p</i><0.01; *** <i>p</i><0.001compared to its WT group; <sup># </sup><i>p</i><0.05, compared to Akita group.</p
<p>(A) Groups of BALB/c and CBA mice (n = 4) were infected with <i>L. major</i> parasites in one hin...
Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiologic...
We have recently found that diabetes-induced premature senescence of retinal endothelial cells is ac...
<p>Time-course analysis showed significant increases in arginase activity in diabetic mice (12 and 2...
<div><p>Background</p><p>Elevated arginase (Arg) activity is reported to be involved in diabetes-ind...
Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular endothelial...
Background: Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular...
OBJECTIVE—To determine 1) whether renal arginase activity or expression is increased in diabetes and...
<p>EFS-induced nitrergic relaxations (1–32 Hz) were performed at 4 (panel <b>A</b>), 12 and 24 weeks...
<p>Protein levels of nNOS were analysed in non-diabetic and diabetic cavernosal tissues at 12 and 24...
<p>Lower panel shows relation between arginase I or II expression and β-actin. Results (mean ± S.E.M...
<p>(A) Western blot analysis of arginase 1 (B) Densitometry of arginase 1 (C) Quantitative morphomet...
<p>Relaxation was induced by a single dose of ACh (1 µmol/l) in aorta (panel <b>A</b> and <b>B</b>) ...
Background: Nitric oxide (NO) is an important biological messenger in the cardiovascular system. NO ...
Endothelial arginase 1 was ablated to assess whether this prevents hyperglycemia- induced endothelia...
<p>(A) Groups of BALB/c and CBA mice (n = 4) were infected with <i>L. major</i> parasites in one hin...
Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiologic...
We have recently found that diabetes-induced premature senescence of retinal endothelial cells is ac...
<p>Time-course analysis showed significant increases in arginase activity in diabetic mice (12 and 2...
<div><p>Background</p><p>Elevated arginase (Arg) activity is reported to be involved in diabetes-ind...
Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular endothelial...
Background: Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular...
OBJECTIVE—To determine 1) whether renal arginase activity or expression is increased in diabetes and...
<p>EFS-induced nitrergic relaxations (1–32 Hz) were performed at 4 (panel <b>A</b>), 12 and 24 weeks...
<p>Protein levels of nNOS were analysed in non-diabetic and diabetic cavernosal tissues at 12 and 24...
<p>Lower panel shows relation between arginase I or II expression and β-actin. Results (mean ± S.E.M...
<p>(A) Western blot analysis of arginase 1 (B) Densitometry of arginase 1 (C) Quantitative morphomet...
<p>Relaxation was induced by a single dose of ACh (1 µmol/l) in aorta (panel <b>A</b> and <b>B</b>) ...
Background: Nitric oxide (NO) is an important biological messenger in the cardiovascular system. NO ...
Endothelial arginase 1 was ablated to assess whether this prevents hyperglycemia- induced endothelia...
<p>(A) Groups of BALB/c and CBA mice (n = 4) were infected with <i>L. major</i> parasites in one hin...
Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiologic...
We have recently found that diabetes-induced premature senescence of retinal endothelial cells is ac...