Epitope fine mapping of ATROSAB analyzed by binding to TNFR1 mutants in ELISA.

Analysis of ATROSAB for binding to human soluble Fcγ receptors and human complement protein C1q and the lack of the induction of ADCC and CDC.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

Binding of immobilized ATROSAB and Trastuzumab to human soluble Fcγ receptor IA (a), Fcγ receptor...

Three residues in CDR-H3 are important for antigen-antibody binding.

Bong-Kook Ko (777504)
Soyoung Choi (1849450)
Lei Guang Cui (777505)
Young-Ha Lee (422685)
In-Sik Hwang (777506)
Kyu-Tae Kim (137845)
Hyunbo Shim (777507)
Jong-Seo Lee (777508)

July 2015

The binding activities of alanine scanning mutants of CDR-H3 (A) and CDR-L3 (B) wer...

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families

Marles-Wright, Jon
Jones, E. Yvonne

January 2005

Protein-protein recognition plays a central role in the surveillance of self and non-self in the mam...

Binding of ATROSAB and TNF to human TNFR1 mutants in ELISA.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

Details of binding studies are described in <a href="http://www.plosone.org/article/info:doi/10.1...

Mapping of the Epitope of ATROSAB on human TNFR1.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

a) Comparison of amino acids 1–97 of human and mouse TNFR1 b). Positions of the identified residu...

Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity

Richter Fabian
Liebig Timo
Guenzi Eric
Herrmann Andreas
Scheurich Peter
Pfizenmaier Klaus
Kontermann Roland E.

August 2013

Selective inhibition of TNFR1 signaling holds the potential to greatly reduce the pro-inflammatory a...

QCM analysis of human TNFR1 binding by ATROSAB.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

Binding of ATROSAB to human TNFR1 was analyzed by QCM at high (a, b; 130 Hz) and low (c, d; 27 Hz...

Characterization of the agonistic antibody Htr-9.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

a) SEC of purified Htr-9. b) ELISA analyzing binding of Htr-9 and ATROSAB to immobilized human an...

Ligand recognition in mutant proteins

Reed, Charles Christopher

January 1999

Protein recognition events are ubiquitous processes. This thesis work focuses on two proteins and th...

Trafficking of WT and mutated forms of TNFR1 at the cell surface.

Isabelle Jéru (369567)
Serge Charmion (437094)
Emmanuelle Cochet (369569)
Bruno Copin (437095)
Philippe Duquesnoy (65332)
Maria Teresa Mitjavila Garcia (437096)
Gaëlle Le Borgne (430313)
Pascal Cathebras (437097)
Jacques Gaillat (437098)
Sonia Karabina (430316)
Catherine Dodé (141716)
Peter Lohse (233856)
Véronique Hentgen (430312)
Serge Amselem (65335)

July 2013

FACS analysis was performed in HEK293T cells transiently expressing the WT and mutated forms of t...

Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis

Van Ostade, Xaveer
Tavernier, Jan
Prangé, Thierry
Fiers, Walter

January 1991

In order to define the active site(s) of human tumour necrosis factor (hTNF), we mutagenized its gen...

Effect of mutating Lys residues on the cell surface and total expression of AT1R.

Xiaoping Zhang (124848)
Hong Wang (13528)
Matthew T. Duvernay (382190)
Shu Zhu (356373)
Guangyu Wu (295586)

February 2013

(A) AT1R and its mutants K310E, K311E and 4K–4E were either tagged with three HA at their N-termi...

1F1 epitope overlaps the receptor binding site.

Tshidi Tsibane (113683)
Damian C. Ekiert (113685)
Jens C. Krause (113687)
Osvaldo Martinez (113689)
James E. Crowe Jr. (113691)
Ian A. Wilson (113692)
Christopher F. Basler (113693)

December 2012

1F1 recognizes several residues involved in binding sialic acid receptors (red spheres). Addition...

Affinity gains by target-binding screening and NGS approaches.

Dongmei Hu (30841)
Siyi Hu (750160)
Wen Wan (95714)
Man Xu (406648)
Ruikai Du (750161)
Wei Zhao (14321)
Xiaolian Gao (9564)
Jing Liu (38537)
Haiyan Liu (51889)
Jiong Hong (750162)

June 2015

The scFv-Fc mutants were expressed in Expi293 cells to determine their apparent binding affinitie...

Structural mapping of TNAP M4 mutants.

Marc F. Hoylaerts (357445)
Soetkin Van kerckhoven (702911)
Tina Kiffer-Moreira (526489)
Campbell Sheen (702912)
Sonoko Narisawa (320584)
José Luis Millán (3966677)

March 2015

Degree of binding of TNAP and the indicated TNAP mutants to four epitope-mapped monoclonal anti-T...

Analysis of ATROSAB for binding to human soluble Fcγ receptors and human complement protein C1q and the lack of the induction of ADCC and CDC.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

Binding of immobilized ATROSAB and Trastuzumab to human soluble Fcγ receptor IA (a), Fcγ receptor...

Three residues in CDR-H3 are important for antigen-antibody binding.

Bong-Kook Ko (777504)
Soyoung Choi (1849450)
Lei Guang Cui (777505)
Young-Ha Lee (422685)
In-Sik Hwang (777506)
Kyu-Tae Kim (137845)
Hyunbo Shim (777507)
Jong-Seo Lee (777508)

July 2015

The binding activities of alanine scanning mutants of CDR-H3 (A) and CDR-L3 (B) wer...

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families

Marles-Wright, Jon
Jones, E. Yvonne

January 2005

Protein-protein recognition plays a central role in the surveillance of self and non-self in the mam...

Binding of ATROSAB and TNF to human TNFR1 mutants in ELISA.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

Details of binding studies are described in <a href="http://www.plosone.org/article/info:doi/10.1...

Mapping of the Epitope of ATROSAB on human TNFR1.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

a) Comparison of amino acids 1–97 of human and mouse TNFR1 b). Positions of the identified residu...

Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity

Richter Fabian
Liebig Timo
Guenzi Eric
Herrmann Andreas
Scheurich Peter
Pfizenmaier Klaus
Kontermann Roland E.

August 2013

Selective inhibition of TNFR1 signaling holds the potential to greatly reduce the pro-inflammatory a...

QCM analysis of human TNFR1 binding by ATROSAB.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

Binding of ATROSAB to human TNFR1 was analyzed by QCM at high (a, b; 130 Hz) and low (c, d; 27 Hz...

Characterization of the agonistic antibody Htr-9.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

a) SEC of purified Htr-9. b) ELISA analyzing binding of Htr-9 and ATROSAB to immobilized human an...

Ligand recognition in mutant proteins

Reed, Charles Christopher

January 1999

Protein recognition events are ubiquitous processes. This thesis work focuses on two proteins and th...

Trafficking of WT and mutated forms of TNFR1 at the cell surface.

Isabelle Jéru (369567)
Serge Charmion (437094)
Emmanuelle Cochet (369569)
Bruno Copin (437095)
Philippe Duquesnoy (65332)
Maria Teresa Mitjavila Garcia (437096)
Gaëlle Le Borgne (430313)
Pascal Cathebras (437097)
Jacques Gaillat (437098)
Sonia Karabina (430316)
Catherine Dodé (141716)
Peter Lohse (233856)
Véronique Hentgen (430312)
Serge Amselem (65335)

July 2013

FACS analysis was performed in HEK293T cells transiently expressing the WT and mutated forms of t...

Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis

Van Ostade, Xaveer
Tavernier, Jan
Prangé, Thierry
Fiers, Walter

January 1991

In order to define the active site(s) of human tumour necrosis factor (hTNF), we mutagenized its gen...

Effect of mutating Lys residues on the cell surface and total expression of AT1R.

Xiaoping Zhang (124848)
Hong Wang (13528)
Matthew T. Duvernay (382190)
Shu Zhu (356373)
Guangyu Wu (295586)

February 2013

(A) AT1R and its mutants K310E, K311E and 4K–4E were either tagged with three HA at their N-termi...

1F1 epitope overlaps the receptor binding site.

Tshidi Tsibane (113683)
Damian C. Ekiert (113685)
Jens C. Krause (113687)
Osvaldo Martinez (113689)
James E. Crowe Jr. (113691)
Ian A. Wilson (113692)
Christopher F. Basler (113693)

December 2012

1F1 recognizes several residues involved in binding sialic acid receptors (red spheres). Addition...

Affinity gains by target-binding screening and NGS approaches.

Dongmei Hu (30841)
Siyi Hu (750160)
Wen Wan (95714)
Man Xu (406648)
Ruikai Du (750161)
Wei Zhao (14321)
Xiaolian Gao (9564)
Jing Liu (38537)
Haiyan Liu (51889)
Jiong Hong (750162)

June 2015

The scFv-Fc mutants were expressed in Expi293 cells to determine their apparent binding affinitie...

Structural mapping of TNAP M4 mutants.

Marc F. Hoylaerts (357445)
Soetkin Van kerckhoven (702911)
Tina Kiffer-Moreira (526489)
Campbell Sheen (702912)
Sonoko Narisawa (320584)
José Luis Millán (3966677)

March 2015

Degree of binding of TNAP and the indicated TNAP mutants to four epitope-mapped monoclonal anti-T...

Analysis of ATROSAB for binding to human soluble Fcγ receptors and human complement protein C1q and the lack of the induction of ADCC and CDC.

Fabian Richter (447420)
Timo Liebig (447421)
Eric Guenzi (447422)
Andreas Herrmann (362184)
Peter Scheurich (144993)
Klaus Pfizenmaier (47885)
Roland E. Kontermann (235510)

August 2013

Binding of immobilized ATROSAB and Trastuzumab to human soluble Fcγ receptor IA (a), Fcγ receptor...

Three residues in CDR-H3 are important for antigen-antibody binding.

Bong-Kook Ko (777504)
Soyoung Choi (1849450)
Lei Guang Cui (777505)
Young-Ha Lee (422685)
In-Sik Hwang (777506)
Kyu-Tae Kim (137845)
Hyunbo Shim (777507)
Jong-Seo Lee (777508)

July 2015

The binding activities of alanine scanning mutants of CDR-H3 (A) and CDR-L3 (B) wer...

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families

Marles-Wright, Jon
Jones, E. Yvonne

January 2005

Protein-protein recognition plays a central role in the surveillance of self and non-self in the mam...

Epitope fine mapping of ATROSAB analyzed by binding to TNFR1 mutants in ELISA.

Abstract

Extracted data

Epitope fine mapping of ATROSAB analyzed by binding to TNFR1 mutants in ELISA.

Abstract

Extracted data

Related items

Related items