Contribution of ROS to bacterial killing by human non-CF and CF human macrophages.

<p>A) Percentage of live intracellular bacteria rescued from untreated (white bar) and DPI-treated (black bar) macrophages. Samples: MDM, monocyte derived macrophages from non-CF subjects (n = 10) and CF patients (n = 6); Lung, macrophages isolated from lung specimens of non-CF subjects (n = 6) and CF (n = 7) patients. Statistical analysis (Wilcoxon non parametric <i>t</i>-test) DPI <i>vs</i> untreated: non-CF MDMs *<i>p = </i>0.002; CF MDMs, *<i>p = </i>0.03; lung non-CF macrophages, *<i>p = </i>0.031; lung CF macrophages *<i>p = </i>0.015. B) Fold increase of live intracellular bacteria in DPI-treated macrophages <i>versus</i> untreated macrophages. Each symbol represents a single subject, and the line is the mean fold increase.