Combined effects of increasing numbers of isolated postprandial hyperglycaemia-associated risk alleles from <i>TCF7L2</i>, <i>CDKAL1</i>, <i>KCNQ1</i>, <i>PRC1</i>, <i>TP53INP1</i> and <i>GCKR</i>.

<p>A: The isolated postprandial hyperglycaemia-associated risk allele distribution in controls, participants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia. Each additional risk allele increased the risk of isolated postprandial hyperglycaemia by 1.19-fold (<i>p</i><0.0001) (B) but not the risk of isolated fasting hyperglycaemia (C). OR and 95% CI were plotted on the y-axis for the corresponding number of risk alleles on the x-axis (black circles = risk of isolated fasting hyperglycaemia; white circles = risk of isolated postprandial hyperglycaemia). B: Participants harboring eight or more risk alleles had a 2.31-fold increased risk for isolated postprandial hyperglycaemia (<i>p</i><0.0001) compared with the reference group. C: However, risk for isolated fasting hyperglycaemia was not increased as risk allele number increasing. IFH, isolated fasting hyperglycemia; IPH, isolated postprandial hyperglycemia.