Recruitment of different ‘bystander’ cell populations into the pancreatic target tissue.

<p>PD-L1^−/− mice were immunized with both, pCI/ppins+pCI/ppinsΔA_12–21 vectors into the right and the left tibialis anterior muscles, respectively. Pancreata of representative healthy (at 3 days post immunization) (A) or early diabetic mice (at 15–20 days post immunization) (B) were analyzed histologically for insulin expression (insulin) and influx of CD4⁺ T-cells (CD4⁺), macrophages (F4/80⁺) or DCs (CD11c⁺).