Effect of miR-29b <i>in vivo</i> on cardiac fibrotic gene related expression.

<p>(A): qPCR analysis for miR-29b expression in infarcted heart at 3 days or 28 days. *p<0.05 vs. Sham group. All values expressed as mean ± SEM. n = 3 for each group. (B): qPCR analysis for miR-29b expression in infarcted area, border area, and remote area 3 days post-MI, respectively. Sham, sham operated group with loose suture around LAD; MI, myocardial infarction; IF, infarcted area; B, border area; R, remote area. *p<0.05 vs. Sham group. All values expressed as mean ± SEM. n = 3 for each group. (C-1): qPCR analysis of miR-29b expression in heart after <i>in vivo</i> administration. Quantitative data for fibrosis related genes including exprression of TGF-β1 (C-2), SDF-1α (C-3), MRTF-A (C-4) collagen I (C-5), and collagen III (C-6) in infarcted heart 3 days after intramyocardial gene delivery of control mimic (Ctrl), miR-29b1 mimic (miR-29b), or miR-29b1 inhibitor (Anti-29b). *p<0.05 vs. CFb^Ctrl; ^†p<0.05 vs. CFb^miR-29b. All values expressed as mean ± SEM. n = 4 for each group.