Mutation of the phosphorylated residues in the SPRR cause reduced virulence.

<p>(A) Kaplan-Meier survival curve showing virulence analysis in a murine inhalational model of invasive aspergillosis. At day 14 post-infection, mice infected with the WT strain displayed 90% mortality, in contrast to the cnaA^mt-4SA strain which exhibited a significant reduction in virulence (<i>P</i><0.0001). (B) Histopathological examination of the lungs shows less inflammation in the cnaA^mt-4SA strain as well as significantly less hyphal invasion.