Lesion apoptosis is unaffected by p110γ deletion.

<p>Atherosclerotic plaques were analyzed in LDLR^−/−p110γ^+/− and LDLR^−/−p110γ^−/− mice after a two-month high-fat diet. (<b>A</b>) Representative photomicrographs of TUNEL immunofluorescent staining for lesion apoptosis in aortic sections from LDLR^−/−p110γ^+/− (<i>n</i> = 8) and LDLR^−/−p110γ^−/− mice (<i>n</i> = 8) (top); percentage of TUNEL⁺ relative to total cells in the delimited lesion area (bottom<u>)</u>. Bar = 50 μm. (<b>B</b>) Representative photomicrographs of cleaved caspase-3 immunofluorescent staining for lesion apoptosis in aortic sections from LDLR^−/−p110γ^+/− (<i>n</i> = 5) and LDLR^−/−p110γ^−/− mice (<i>n</i> = 5) (top); percentage of cleaved caspase-3⁺ relative to total cells in the delimited lesion area (bottom). Bar = 50 μm. Mean ± SD; Student’s <i>t</i>-test.