<p><i>A</i>, Bone marrow-derived macrophages from B6 mice were treated with or without stimulatory anti-CD40 mAb. Cell lysates were used to probe for p-PKR, PKR, phospho-eIF2α and eIF2α by WB. <i>B</i>, Bone marrow-derived macrophages from wild-type, IFN-γ<sup>−/−</sup>, TNF-α<sup>−/−</sup>, IL-1R<sup>−/−</sup>, IFN-α/βR<sup>−/−</sup> or PACT<sup>−/−</sup> mice were treated with or without stimulatory anti-CD40 mAb. Cell lysates obtained after 30 min of <i>in vitro</i> stimulation were used to probe for p-PKR and PKR by WB. Results shown are representative of 3 independent experiments.</p
Chronic allograft nephropathy (CAN) is the main cause of renal graft loss, but its pathogenic mechan...
B lymphocytes need two signals in order to differentiate into antibody-producing cells, one deliver...
Depending on the strength of signal dose, CD40 receptor (CD40) controls ERK-1/2 and p38MAPK activati...
<p><i>A</i>, RAW 264.7 cells that express WT hmCD40 or hmCD40 with mutations at the TRAF2/TRAF3 bind...
<p>Bone marrow-derived macrophages (<i>A, B</i>) or primary brain microglia (<i>C</i>) from B6 or PK...
<p>(A) Freshly isolated PM of normal and infected mice were stained with F4/80-FITC and CD40-PE and ...
<p>(A) Autophosphorylation of PKR in macrophages at the indicated times after addition of IFN-gamma ...
Tracts were incubated with radioactively labeled DNA oligonucleotides containing a NF-κB binding sit...
CD40 plays important roles in cell-mediated and humoral immune responses. In this study, we explored...
<p>Four kinases: syk, Raf-1, MEK-1/2 and ERK-1/2 exhibit reduced (A), whereas the other four kinases...
<div><p>Depending on the strength of signal dose, CD40 receptor (CD40) controls ERK-1/2 and p38MAPK ...
AbstractThe interaction of the CD40 receptor with its ligand has been shown to be crucial for the ac...
AbstractCD40 stimulation, by either antibody or ligand, has been shown to inhibit the growth of a va...
<p>Confluent HAEC were exposed to CD40L (80 ng/mL, 1 h), and the translocation of PKCβ and PKCβ phos...
<p>(<b>a</b>) Preincubation of peripheral blood mononuclear cells (PBMC) of controls without (w/o) o...
Chronic allograft nephropathy (CAN) is the main cause of renal graft loss, but its pathogenic mechan...
B lymphocytes need two signals in order to differentiate into antibody-producing cells, one deliver...
Depending on the strength of signal dose, CD40 receptor (CD40) controls ERK-1/2 and p38MAPK activati...
<p><i>A</i>, RAW 264.7 cells that express WT hmCD40 or hmCD40 with mutations at the TRAF2/TRAF3 bind...
<p>Bone marrow-derived macrophages (<i>A, B</i>) or primary brain microglia (<i>C</i>) from B6 or PK...
<p>(A) Freshly isolated PM of normal and infected mice were stained with F4/80-FITC and CD40-PE and ...
<p>(A) Autophosphorylation of PKR in macrophages at the indicated times after addition of IFN-gamma ...
Tracts were incubated with radioactively labeled DNA oligonucleotides containing a NF-κB binding sit...
CD40 plays important roles in cell-mediated and humoral immune responses. In this study, we explored...
<p>Four kinases: syk, Raf-1, MEK-1/2 and ERK-1/2 exhibit reduced (A), whereas the other four kinases...
<div><p>Depending on the strength of signal dose, CD40 receptor (CD40) controls ERK-1/2 and p38MAPK ...
AbstractThe interaction of the CD40 receptor with its ligand has been shown to be crucial for the ac...
AbstractCD40 stimulation, by either antibody or ligand, has been shown to inhibit the growth of a va...
<p>Confluent HAEC were exposed to CD40L (80 ng/mL, 1 h), and the translocation of PKCβ and PKCβ phos...
<p>(<b>a</b>) Preincubation of peripheral blood mononuclear cells (PBMC) of controls without (w/o) o...
Chronic allograft nephropathy (CAN) is the main cause of renal graft loss, but its pathogenic mechan...
B lymphocytes need two signals in order to differentiate into antibody-producing cells, one deliver...
Depending on the strength of signal dose, CD40 receptor (CD40) controls ERK-1/2 and p38MAPK activati...