Anxiety-related, activity and exploratory measures in the light-dark box test.

<p>Mice with an XY karyotype spent a greater proportion of time in the dark compartment of the apparatus than mice with an XX karyotype, irrespective of gonadal type (<b>A</b>, *p<0.05). The four experimental groups displayed equivalent numbers of transitions between the two boxes (B). Gonadally male mice tended to take longer than gonadally female mice to enter the aversive light box (C) irrespective of karyotype (*p<0.05). The four experimental groups demonstrated equivalent degrees of exploratory behaviour as indexed by rearing (<b>D</b>).