Subretinal delivery of AAV encoding human Myo7a improves recovery from light desensitization in adult <i>sh1^−/−</i> mice.

<p>The graph shows the recovery from light desensitization in albino <i>sh1^−/−</i> mice 6 months following AAV injection. The relative b-wave is the ratio between the post- and the pre-desensitization b-wave amplitudes (µV) both evoked by 1 cd*s/m². The time (minutes) refers to the time post-desensitization. To assess statistical significance Two-way ANOVA was used: the statistical significant differences between <i>sh1^+/−</i> and <i>sh1^−/−</i> mice from the post-hoc Multiple Comparison Procedure are depicted: *p value<0.05; ** and # p<0.001. Asterisks label significant differences between <i>hMYOA</i>- and <i>EGFP</i>-treated eyes; pound keys label significant differences between <i>EGFP</i>-treated eyes and <i>sh1^+/−</i> eyes. More details on the statistical analysis can be found in the Statistical analysis paragraph of the Materials and Methods section. AAV-<i>hMYO7A</i>: AAV2/5-CMV-<i>hMYO7A</i>; AAV-<i>EGFP:</i> AAV2/5-CMV-<i>EGFP.</i>