MAbs and HIVIG competition with 1F7 binding to gp120.
- Johannes S. Gach (244457)
- Heribert Quendler (108436)
- Tommy Tong (426980)
- Kristin M. Narayan (105322)
- Sean X. Du (105326)
- Robert G. Whalen (105336)
- James M. Binley (426982)
- Donald N. Forthal (372785)
- Pascal Poignard (244468)
- Michael B. Zwick (105335)
Publication date
August 2013
DOIAbstract
<p>MAbs b6, 15e, b12, HIVIG, F425-b4e8, VRC03, and VRC01 were co-incubated with a constant concentration of biotinylated mAb 1F7 and allowed to bind to immobilized gp120<sub>JR-FL</sub>. Curves were analyzed with GraphPad Prism 5.04 using a three-parameter fit with shared values for maximum and minimum binding. Data are representative of at least 3 titrations of each MAb against biotinylated mAb 1F7.</p
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