2OAA attenuates the LPS-induced increase in serum TNF-α levels in C57BL6/J mice.

<p><b>A</b>. Bar diagram showing the dose-dependent inhibition of serum TNF-α by 2OAA (50, 200 and 500 mg/kg) in LPS-challenged C57BL6/J mice (100%: *** <i>p</i><0.001 with respect to the LPS-challenged controls). <b>B</b>. Bar diagram showing the inhibitory effects of cortisone (12.5 mg/kg; Co), ibuprofen (7.5 mg/kg; Ib) and 2OAA (500 mg/kg) on serum TNF-α in LPS-challenged C57BL6/J mice (*** <i>p</i><0.001 with respect to controls; † <i>p</i><0.05 with respect to Ib).