Distribution of adenosine receptors A₁, A_2A, A_2B and A₃ receptors in the neuromuscular layer of rat ileum during HSV-1 infection.

<p>Representative immunofluorescence staining of adenosine receptors A₁, A_2A, A_2B and A₃ in ileal sections from control (sham) and HSV-1-treated rats 1 and 6 weeks (w) after intragastric administration. Immunofluorescence analyses revealed expression of all four adenosine receptors in smooth muscle layers and myenteric ganglia of control ileum as well as changes in their immunoreactivity, both at the ganglionic level and in smooth muscle layers over the time-course of viral infection. The boxed areas (panel A) are enlarged at right (panel B) to show the distribution of the adenosine receptors in the neuromuscular layer. Scale bar: 50 µm (panel A); 25 µm (panel B). CM, circular muscle; LM, longitudinal muscle; *, myenteric ganglia.