Histopathology of induced and spontaneous uveitis models.

<p><b>A–D,</b> Mice were immunized with IRBP in adjuvant and eyes were collected at the indicated days after immunization. Note severe ocular inflammation including vitritis, retinal swelling and destruction, retinal folds and infiltrates, subretinal hemorrhage, and choroidal inflammation at the peak of inflammation on day 14 p.i. (A–B, low and high magnification). During the acute phase of EAU, 18–21 days after immunization, eye histology showed well developed retinal lesions and infiltrating cells in the choroid, vitreous, as well as subretinal hemorrhage (arrow) (B and C). Retinal folds were seen in mice that developed the chronic form of EAU (D). <b>E–H,</b> Histology of R161H mice at different ages. Note cellular infiltrates and exudates in the vitreous and in the retina (E–F, low and high magnification), lymphoid aggregation in the retina (G, asterisk), photoreceptor layer destruction (H) and choroidal inflammation (G–H). <b>I–P,</b> Histology of AIRE^−/− mice at different ages. Note severe choroiditis (I–J, low magnification; N, high magnification), granuloma-like lesions in the retina (K, low magnification; M–N, high magnification), photoreceptor layer destruction and retinal degeneration (O–P, high magnification). Fourteen B10RIII mice with EAU (10 for monophasic form, 4 for chronic form), 12 R161H and 13 AIRE^−/− mice were included in the histological examination. Eyes of 2–3 mice were harvested at each time point.