Histological evaluation of anti-inflammatory effects of Gelam honey.

<p>Hematoxylin and Eosin staining of paw tissues of rats pre-treated with: (<b>A</b>) D.W., (<b>B</b>) 2 g/kg Gelam honey, (<b>C</b>) D.W.+Carr., (<b>D</b>) 2 g/kg Gelam honey for 1 day+Carr. (<b>E</b>) 2 g/kg Gelam honey for 7 days+Carr. and (<b>F</b>) 10 mg/kg IND.+Carr., in the model of carrageenan-induced edema. Each photo is representative of six specimens for each group. All figures were magnified by 200X. (<b>G</b>) Scores of inflammation in rats paw tissues by Hematoxylin and Eosin staining. Data are expressed as mean ± S.E.M. (n = 6). D.W: Distilled water, Carr.: Carrageenan and IND: Indomethacin. <b>a</b>: Significantly different (<i>p</i><0.05) from the inflammation group (D.W.+Carr.). <b>b</b>: Significantly different (<i>p</i><0.05) from the Indomethacin group (10 mg/kg IND+Carr.). <b>c</b>: Significantly different (<i>p</i><0.05) between different honey doses at the same time point (1 day or 7 days). <b>d</b>: Significantly different (<i>p</i><0.05) between the same honey dose at different time points (1 day and 7 days). The arrows indicated inflammatory cells.