Description of isoform multiplicity co-occurrence (IMco).

<p>The figure illustrates how IMco is computed. We start from a set of human-mouse orthologs for which isoform annotations are available in ENSEMBL (or VEGA), as shown in (A). We will say that one gene has isoform multiplicity (IM) when it has more than one isoform. The scheme shows different instances that cover all possible IM combinations for human-mouse ortholog pairs: both orthologs have IM, only one has IM, and no ortholog has IM. (B) IMco will correspond to the fraction of cases for which both orthologs have IM; it is computed as shown in the table.