Lymphatic maturation and blood vessel patterning are normal in <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice.

<p>Whole-mount immunofluorescence staining of ear skin from adult <i>Vegfr2^flox/flox</i> and <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice for Lyve-1 (A,B), smooth muscle actin (A,B), and CD31 (C-F). (A,B) Lyve-1 positive lymphatic vessels are not covered by SMA positive cells in <i>Vegfr2^flox/flox</i> or <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice. (C,D) CD31 expressing lymphatic valves are present in the collecting vessels of <i>Vegfr2^flox/flox</i> and <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice. (E,F) The patterning of CD31 labeled blood vessels is similar for <i>Vegfr2^flox/flox</i> and <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice.