<i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice exhibit a deficiency of dermal lymphatic vessels.

<p>(A,B) Whole-mount immunofluorescence staining of ear skin from <i>Vegfr2^flox/flox</i> and <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice for Lyve-1. (C) Quantitative analysis showing that there are significantly fewer lymphatic branch points in the ear skin of <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> mice (6.042±0.198, n = 6) than <i>Vegr2^flox/flox</i> mice (11.29±0.940, n = 6). (D) Lymphatic vessel diameter is not significantly different between <i>Lyve-1^wt/Cre;Vegfr2^flox/flox</i> (52.65 µm±1.303, n = 6) and <i>Vegfr2^flox/flox</i> mice (49.05 µm±1.675, n = 6). *** indicates P || 0.001.